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Carboxy-PTIO potassium
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Catalog No. T22623Cas No. 148819-94-7
Alias cPTIO potassium
Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.
Carboxy-PTIO potassium
🥰Excellent
Catalog No. T22623Alias cPTIO potassiumCas No. 148819-94-7
Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $79 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2. |
| In vitro | In A375-S2 cells, Carboxy-PTIO potassium (200 μM, 1 h before Physalin A，24 h) reverses Physalin A-induced reduction in mTOR and p-mTOR levels, while inhibiting the conversion of LC3I to LC3II in A375-S2 cells. [1] |
| In vivo | Carboxy-PTIO potassium (0.056-1.70 mg/kg/min, intravenous) treatment improved hypotension, renal dysfunction, and survival in LPS-treated rats. Carboxy-PTIO potassium did not affect the parameters of normal mice. [2] |
| Alias | cPTIO potassium |
| Molecular Weight | 315.39 |
| Formula | C14H16KN2O4 |
| Cas No. | 148819-94-7 |
| Smiles | [O-]C(C1=CC=C(C(N([O])C(C)(C)C2(C)C)=N2=O)C=C1)=O.[K+] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8.00 mg/mL (25.37 mM), Sonication is recommended. H2O: Soluble | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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