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Carboxy-PTIO potassium
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Catalog No. T22623Cas No. 148819-94-7
Alias cPTIO potassium
Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.
Carboxy-PTIO potassium
🥰Excellent
Catalog No. T22623Alias cPTIO potassiumCas No. 148819-94-7
Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $79 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Carboxy-PTIO potassium (cPTIO potassium) is a nitric oxide (NO) scavenger in endothelial cells, inhibiting pterin accumulation and exhibiting neuroprotective activity. It reacts rapidly with NO to produce NO2. |
| In vitro | In A375-S2 cells, Carboxy-PTIO potassium (200 μM, 1 h before Physalin A，24 h) reverses Physalin A-induced reduction in mTOR and p-mTOR levels, while inhibiting the conversion of LC3I to LC3II in A375-S2 cells. [1] |
| In vivo | Carboxy-PTIO potassium (0.056-1.70 mg/kg/min, intravenous) treatment improved hypotension, renal dysfunction, and survival in LPS-treated rats. Carboxy-PTIO potassium did not affect the parameters of normal mice. [2] |
| Alias | cPTIO potassium |
| Molecular Weight | 315.39 |
| Formula | C14H16KN2O4 |
| Cas No. | 148819-94-7 |
| Smiles | [O-]C(C1=CC=C(C(N([O])C(C)(C)C2(C)C)=N2=O)C=C1)=O.[K+] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8.00 mg/mL (25.37 mM), Sonication is recommended. H2O: Soluble | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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